Positive Modulatory Interactions of NMDA Receptor GluN1/2B Ligand Binding Domains Attenuate Antagonists Activity

Positive Modulatory Interactions of NMDA Receptor GluN1/2B Ligand Binding Domains Attenuate Antagonists Activity

N-methyl D-aspartate receptors (NMDAR) play crucial role in normal brain function and pathogenesis of neurodegenerative and psychiatric disorders. Functional tetra-heteromeric NMDAR contains two obligatory GluN1 subunits and two identical or different non-GluN1 subunits that include six different ge...

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Bibliographic Details
Main Authors: Douglas Bledsoe, Ceyhun Tamer, Ivana Mesic, Christian Madry, Bradley G. Klein, Bodo Laube, Blaise M. Costa
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-05-01
Series:Frontiers in Pharmacology
Subjects:
NMDA receptor
Ligand Binding Domain (LBD)
competitive antagonists
memantine
interface
Online Access:http://journal.frontiersin.org/article/10.3389/fphar.2017.00229/full

Internet

http://journal.frontiersin.org/article/10.3389/fphar.2017.00229/full

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