Novel mutant mouse line emphasizes the importance of protein kinase C theta for CD4+ T lymphocyte activation

Novel mutant mouse line emphasizes the importance of protein kinase C theta for CD4+ T lymphocyte activation

Abstract Background The protein kinase C theta (PKCθ) has an important and non-redundant function downstream of the antigen receptor and co-receptor complex in T lymphocytes. PKCθ is not only essential for activation of NF-κB, AP-1 and NFAT and subsequent interleukin-2 expression, but also critical...

Full description

Bibliographic Details
Main Authors: Kerstin Siegmund, Nikolaus Thuille, Nina Posch, Friedrich Fresser, Michael Leitges, Gottfried Baier
Format: Article
Language:English
Published: BMC 2019-05-01
Series:Cell Communication and Signaling
Subjects:
T lymphocyte signaling and activation
Protein kinase C theta (PKCθ)
Interleukin- 2 (IL-2)
Regulatory T cell development
Online Access:http://link.springer.com/article/10.1186/s12964-019-0364-0

Internet

http://link.springer.com/article/10.1186/s12964-019-0364-0

Similar Items