Chronic myeloid leukemia: the paradigm of targeting oncogenic tyrosine kinase signaling and counteracting resistance for successful cancer therapy

Chronic myeloid leukemia: the paradigm of targeting oncogenic tyrosine kinase signaling and counteracting resistance for successful cancer therapy

Abstract Deregulated activity of BCR-ABL1, a nonreceptor tyrosine kinase encoded by the fusion gene resulting from the t(9;22)(q34;q11) chromosomal translocation, is thought to be the driver event responsible for initiation and maintenance of chronic myeloid leukemia (CML). BCR-ABL1 was one of the f...

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Bibliographic Details
Main Authors: Simona Soverini, Manuela Mancini, Luana Bavaro, Michele Cavo, Giovanni Martinelli
Format: Article
Language:English
Published: BMC 2018-02-01
Series:Molecular Cancer
Subjects:
BCR-ABL1
Tyrosine kinase
Tyrosine kinase inhibitors
Resistance
Online Access:http://link.springer.com/article/10.1186/s12943-018-0780-6

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http://link.springer.com/article/10.1186/s12943-018-0780-6

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