Simulated Microgravity Reduces Focal Adhesions and Alters Cytoskeleton and Nuclear Positioning Leading to Enhanced Apoptosis via Suppressing FAK/RhoA-Mediated mTORC1/NF-κB and ERK1/2 Pathways

Simulated Microgravity Reduces Focal Adhesions and Alters Cytoskeleton and Nuclear Positioning Leading to Enhanced Apoptosis via Suppressing FAK/RhoA-Mediated mTORC1/NF-κB and ERK1/2 Pathways

Simulated-microgravity (SMG) promotes cell-apoptosis. We demonstrated that SMG inhibited cell proliferation/metastasis via FAK/RhoA-regulated mTORC1 pathway. Since mTORC1, NF-κB, and ERK1/2 signaling are important in cell apoptosis, we examined whether SMG-enhanced apoptosis is regulated v...

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Bibliographic Details
Main Authors: Tuo Zhao, Rong Li, Xin Tan, Jun Zhang, Cuihong Fan, Qin Zhao, Yulin Deng, Aizhang Xu, Kiven Erique Lukong, Harald Genth, Jim Xiang
Format: Article
Language:English
Published: MDPI AG 2018-07-01
Series:International Journal of Molecular Sciences
Subjects:
SMG
apoptosis
focal adhesion complex
cytoskeleton
nuclear positioning
FAK
RohA
mTORC1
NK-κB
ERK1/2
Online Access:http://www.mdpi.com/1422-0067/19/7/1994

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http://www.mdpi.com/1422-0067/19/7/1994

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