Non-lethal sonodynamic therapy facilitates the M1-to-M2 transition in advanced atherosclerotic plaques via activating the ROS–AMPK–mTORC1–autophagy pathway

Non-lethal sonodynamic therapy facilitates the M1-to-M2 transition in advanced atherosclerotic plaques via activating the ROS–AMPK–mTORC1–autophagy pathway

Emerging evidence indicates that macrophage functional polarization is critically involved in the development of atherosclerosis (AS). Here, we examined the role of 5-aminolaevulinic acid (ALA)-mediated non-lethal sonodynamic therapy (NL-SDT) in macrophage-subset polarization and atherosclerotic les...

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Bibliographic Details
Main Authors: Yang Yang, Jiayu Wang, Shuyuan Guo, Shirin Pourteymour, Qiulian Xu, Jie Gong, Zhen Huang, Zhaoqian Shen, Kamal Diabakte, Zhengyu Cao, Guodong Wu, Sukhareva Natalia, Zhen Tian, Hong Jin, Ye Tian
Format: Article
Language:English
Published: Elsevier 2020-05-01
Series:Redox Biology
Subjects:
Atherosclerosis
Non-lethal sonodynamic therapy
Macrophage polarization
AMPK
mTORC1
Autophagy
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231720300471

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http://www.sciencedirect.com/science/article/pii/S2213231720300471

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