Surrogate endpoints for overall survival in anti-programmed death-1 and anti-programmed death ligand 1 trials of advanced melanoma

Background: We assessed the surrogacy of objective response rate (ORR), disease control rate (DCR) and progression-free survival (PFS) for overall survival (OS) in anti-PD-1/PD-L1 trials of metastatic melanoma through a meta-analysis of randomized controlled trials (RCTs). Methods: PubMed and EMBASE...

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Main Authors: Run-Cong Nie, Shu-Qiang Yuan, Yun Wang, Xue-Bin Zou, Shi Chen, Shu-Man Li, Jin-Ling Duan, Jie Zhou, Guo-Ming Chen, Tian-Qi Luo, Zhi-Wei Zhou, Yuan-Fang Li
Format: Article
Language:English
Published: SAGE Publishing 2020-06-01
Series:Therapeutic Advances in Medical Oncology
Online Access:https://doi.org/10.1177/1758835920929583