Early-Life Stress Regulates Cardiac Development through an IL-4-Glucocorticoid Signaling Balance

Early-Life Stress Regulates Cardiac Development through an IL-4-Glucocorticoid Signaling Balance

Summary: Stressful experiences early in life can increase the risk of cardiovascular diseases. However, it remains largely unknown how stress influences susceptibility to the disease onset. Here, we show that exposure to brain-processed stress disrupts myocardial growth by reducing cardiomyocyte mit...

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Bibliographic Details
Main Authors: Dilem C. Apaydin, Paul A. Morocho Jaramillo, Laura Corradi, Francesca Cosco, Fritz G. Rathjen, Thomas Kammertoens, Alessandro Filosa, Suphansa Sawamiphak
Format: Article
Language:English
Published: Elsevier 2020-11-01
Series:Cell Reports
Subjects:
stress
cytokine
interleukin-4
glucocorticoid
heart development
zebrafish
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124720313930

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http://www.sciencedirect.com/science/article/pii/S2211124720313930

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