Optimizing checkpoint inhibitors therapy for relapsed or progressive classic Hodgkin lymphoma by multiplex immunohistochemistry of the tumor microenvironment

Optimizing checkpoint inhibitors therapy for relapsed or progressive classic Hodgkin lymphoma by multiplex immunohistochemistry of the tumor microenvironment

Abstract Immune checkpoint‐blocking antibodies have therapeutic activity against relapsed or progressive classic Hodgkin lymphoma (cHL), but Hodgkin Reed‐Sternberg cells can develop resistance to this therapy via multiple mechanisms. To improve the efficacy of immune checkpoint blockade, we need a m...

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Bibliographic Details
Main Authors: Antonino Carbone, Annunziata Gloghini, Giancarlo Pruneri, Riccardo Dolcetti
Format: Article
Language:English
Published: Wiley 2019-06-01
Series:Cancer Medicine
Subjects:
checkpoint blockade
classic Hodgkin lymphoma
immune escape
multiplex immunohistochemistry
resistance
tumor microenvironment
Online Access:https://doi.org/10.1002/cam4.2168

Internet

https://doi.org/10.1002/cam4.2168

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