16-Hydroxycleroda-3,13-dien-15,16-olide Induces Apoptosis in Human Bladder Cancer Cells through Cell Cycle Arrest, Mitochondria ROS Overproduction, and Inactivation of EGFR-Related Signalling Pathways

16-Hydroxycleroda-3,13-dien-15,16-olide Induces Apoptosis in Human Bladder Cancer Cells through Cell Cycle Arrest, Mitochondria ROS Overproduction, and Inactivation of EGFR-Related Signalling Pathways

A clerodane diterpene compound 16-hydroxycleroda-3,13-dien-15,16-olide (CD) is considered a therapeutic agent with pharmacological activities. The present study investigated the mechanisms of CD-induced apoptosis in T24 human bladder cancer cells. CD inhibited cell proliferation in a concentration a...

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Bibliographic Details
Main Authors: Yu-Chi Chen, Po-Yu Wang, Bu-Miin Huang, Yu-Jen Chen, Wei-Chang Lee, Yung-Chia Chen
Format: Article
Language:English
Published: MDPI AG 2020-08-01
Series:Molecules
Subjects:
clerodane diterpene
apoptosis
bladder cancer
epidermal growth factor receptor
cell cycle
Online Access:https://www.mdpi.com/1420-3049/25/17/3958

Internet

https://www.mdpi.com/1420-3049/25/17/3958

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