16-Hydroxycleroda-3,13-dien-15,16-olide Induces Apoptosis in Human Bladder Cancer Cells through Cell Cycle Arrest, Mitochondria ROS Overproduction, and Inactivation of EGFR-Related Signalling Pathways
A clerodane diterpene compound 16-hydroxycleroda-3,13-dien-15,16-olide (CD) is considered a therapeutic agent with pharmacological activities. The present study investigated the mechanisms of CD-induced apoptosis in T24 human bladder cancer cells. CD inhibited cell proliferation in a concentration a...
Main Authors: | Yu-Chi Chen, Po-Yu Wang, Bu-Miin Huang, Yu-Jen Chen, Wei-Chang Lee, Yung-Chia Chen |
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Format: | Article |
Language: | English |
Published: |
MDPI AG
2020-08-01
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Series: | Molecules |
Subjects: | |
Online Access: | https://www.mdpi.com/1420-3049/25/17/3958 |
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