VGF-derived peptide TLQP-21 modulates microglial function through C3aR1 signaling pathways and reduces neuropathology in 5xFAD mice

VGF-derived peptide TLQP-21 modulates microglial function through C3aR1 signaling pathways and reduces neuropathology in 5xFAD mice

Abstract Background Multiomic studies by several groups in the NIH Accelerating Medicines Partnership for Alzheimer’s Disease (AMP-AD) identified VGF as a major driver of Alzheimer’s disease (AD), also finding that reduced VGF levels correlate with mean amyloid plaque density, Clinical Dementia Rati...

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Bibliographic Details
Main Authors: Farida El Gaamouch, Mickael Audrain, Wei-Jye Lin, Noam Beckmann, Cheng Jiang, Siddharth Hariharan, Peter S. Heeger, Eric E. Schadt, Sam Gandy, Michelle E. Ehrlich, Stephen R. Salton
Format: Article
Language:English
Published: BMC 2020-01-01
Series:Molecular Neurodegeneration
Subjects:
Alzheimer
Microglia
VGF
TLQP-21
C3aR1
Complement
Online Access:https://doi.org/10.1186/s13024-020-0357-x

Internet

https://doi.org/10.1186/s13024-020-0357-x

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