Molecular basis for multimerization in the activation of the epidermal growth factor receptor

Molecular basis for multimerization in the activation of the epidermal growth factor receptor

The epidermal growth factor receptor (EGFR) is activated by dimerization, but activation also generates higher-order multimers, whose nature and function are poorly understood. We have characterized ligand-induced dimerization and multimerization of EGFR using single-molecule analysis, and show that...

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Bibliographic Details
Main Authors: Yongjian Huang, Shashank Bharill, Deepti Karandur, Sean M Peterson, Morgan Marita, Xiaojun Shi, Megan J Kaliszewski, Adam W Smith, Ehud Y Isacoff, John Kuriyan
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2016-03-01
Series:eLife
Subjects:
EGFR
stoichiometry
multimerization
Online Access:https://elifesciences.org/articles/14107

Internet

https://elifesciences.org/articles/14107

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