Integrin β1 Optimizes Diabetogenic T Cell Migration and Function in the Pancreas

T cell search behavior is dictated by their need to encounter their specific antigen to eliminate target cells. However, mechanisms controlling effector T cell motility are highly tissue-dependent. Specifically, how diabetogenic T cells encounter their target beta cells in dispersed islets throughou...

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Bibliographic Details
Main Authors: Gabriel Espinosa-Carrasco, Cécile Le Saout, Pierre Fontanaud, Aurélien Michau, Patrice Mollard, Javier Hernandez, Marie Schaeffer
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-05-01
Series:Frontiers in Immunology
Subjects:
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.01156/full