Extracellular α-synuclein levels are regulated by neuronal activity

Abstract Background α-Synuclein is a presynaptic protein abundant in the cytoplasmic compartment of neurons, whereas its presence in the extracellular space has also been observed under physiological conditions. Extracellular α-synuclein has pathological significance, exhibiting cellular toxicity an...

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Bibliographic Details
Main Authors: Kaoru Yamada, Takeshi Iwatsubo
Format: Article
Language:English
Published: BMC 2018-02-01
Series:Molecular Neurodegeneration
Subjects:
Online Access:http://link.springer.com/article/10.1186/s13024-018-0241-0