Xeno-Free and Defined Human Embryonic Stem Cell-Derived Retinal Pigment Epithelial Cells Functionally Integrate in a Large-Eyed Preclinical Model

Xeno-Free and Defined Human Embryonic Stem Cell-Derived Retinal Pigment Epithelial Cells Functionally Integrate in a Large-Eyed Preclinical Model

Human embryonic stem cell (hESC)-derived retinal pigment epithelial (RPE) cells could replace lost tissue in geographic atrophy (GA) but efficacy has yet to be demonstrated in a large-eyed model. Also, production of hESC-RPE has not yet been achieved in a xeno-free and defined manner, which is criti...

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Bibliographic Details
Main Authors: Alvaro Plaza Reyes, Sandra Petrus-Reurer, Liselotte Antonsson, Sonya Stenfelt, Hammurabi Bartuma, Sarita Panula, Theresa Mader, Iyadh Douagi, Helder André, Outi Hovatta, Fredrik Lanner, Anders Kvanta
Format: Article
Language:English
Published: Elsevier 2016-01-01
Series:Stem Cell Reports
Subjects:
human embryonic stem cells
differentiation
retinal pigment epithelium
laminin
xeno-free
cellular therapy
rabbit
transplantation
optical coherence tomography
Online Access:http://www.sciencedirect.com/science/article/pii/S2213671115003446

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http://www.sciencedirect.com/science/article/pii/S2213671115003446

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