OCT4 and PAX6 determine the dual function of SOX2 in human ESCs as a key pluripotent or neural factor

OCT4 and PAX6 determine the dual function of SOX2 in human ESCs as a key pluripotent or neural factor

Abstract Background Sox2 is a well-established pluripotent transcription factor that plays an essential role in establishing and maintaining pluripotent stem cells (PSCs). It is also thought to be a linage specifier that governs PSC neural lineage specification upon their exiting the pluripotent sta...

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Bibliographic Details
Main Authors: Shuchen Zhang, Emma Bell, Huihan Zhi, Sarah Brown, Siti A. M. Imran, Véronique Azuara, Wei Cui
Format: Article
Language:English
Published: BMC 2019-04-01
Series:Stem Cell Research & Therapy
Subjects:
SOX2
OCT4
PAX6
Neural differentiation
Human embryonic stem cells
Online Access:http://link.springer.com/article/10.1186/s13287-019-1228-7

Internet

http://link.springer.com/article/10.1186/s13287-019-1228-7

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