Therapeutic Potential of Sodium Channel Blockers as a Targeted Therapy Approach in KCNA1-Associated Episodic Ataxia and a Comprehensive Review of the Literature

Therapeutic Potential of Sodium Channel Blockers as a Targeted Therapy Approach in KCNA1-Associated Episodic Ataxia and a Comprehensive Review of the Literature

Introduction: Among genetic paroxysmal movement disorders, variants in ion channel coding genes constitute a major subgroup. Loss-of-function (LOF) variants in KCNA1, the gene coding for KV1.1 channels, are associated with episodic ataxia type 1 (EA1), characterized by seconds to minutes-lasting att...

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Bibliographic Details
Main Authors: Stephan Lauxmann, Lukas Sonnenberg, Nils A. Koch, Christian Bosselmann, Natalie Winter, Niklas Schwarz, Thomas V. Wuttke, Ulrike B. S. Hedrich, Yuanyuan Liu, Holger Lerche, Jan Benda, Josua Kegele
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-09-01
Series:Frontiers in Neurology
Subjects:
episodic ataxia
sodium channel blockers
KV1.1
conduction-based model
voltage-gated potassium channels
riluzole
Online Access:https://www.frontiersin.org/articles/10.3389/fneur.2021.703970/full

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https://www.frontiersin.org/articles/10.3389/fneur.2021.703970/full

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