Next-Generation Sequencing and Quantitative Proteomics of Hutchinson-Gilford progeria syndrome-derived cells point to a role of nucleotide metabolism in premature aging.

Next-Generation Sequencing and Quantitative Proteomics of Hutchinson-Gilford progeria syndrome-derived cells point to a role of nucleotide metabolism in premature aging.

Hutchinson-Gilford progeria syndrome (HGPS) is a very rare fatal disease characterized for accelerated aging. Although the causal agent, a point mutation in LMNA gene, was identified more than a decade ago, the molecular mechanisms underlying HGPS are still not fully understood and, currently, there...

Full description

Bibliographic Details
Main Authors: Jesús Mateos, Juan Fafián-Labora, Miriam Morente-López, Iván Lesende-Rodriguez, Lorenzo Monserrat, María A Ódena, Eliandre de Oliveira, Javier de Toro, María C Arufe
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC6209416?pdf=render

Internet

http://europepmc.org/articles/PMC6209416?pdf=render

Similar Items