Activity-dependent isomerization of Kv4.2 by Pin1 regulates cognitive flexibility
K + channels function in macromolecular complexes with accessory subunits to regulate neuronal function. Here, the authors describe Pin1-mediated regulation of the Kv4.2 complex, which impacts reversal learning in mice, providing potential treatment for disorders characterized by cognitive inflexibi...
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2020-03-01
|
| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-020-15390-x |