Optimizing the Relaxivity of MRI Probes at High Magnetic Field Strengths With Binuclear GdIII Complexes

Optimizing the Relaxivity of MRI Probes at High Magnetic Field Strengths With Binuclear GdIII Complexes

The key criteria to optimize the relaxivity of a Gd(III) contrast agent at high fields (defined as the region ≥ 1.5 T) can be summarized as follows: (i) the occurrence of a rotational correlation time τR in the range of ca. 0.2–0.5 ns; (ii) the rate of water exchange is not critical, but a τM &l...

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Bibliographic Details
Main Authors: Loredana Leone, Giuseppe Ferrauto, Maurizio Cossi, Mauro Botta, Lorenzo Tei
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-05-01
Series:Frontiers in Chemistry
Subjects:
gadolinium
macrocyclic ligands
multimeric contrast agents
magnetic resonance imaging-high field
chemical exchange saturation transfer
relaxometry
Online Access:http://journal.frontiersin.org/article/10.3389/fchem.2018.00158/full

Internet

http://journal.frontiersin.org/article/10.3389/fchem.2018.00158/full

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