Complex I reductions in the nucleus basalis of Meynert in Lewy body dementia: the role of Lewy bodies

Complex I reductions in the nucleus basalis of Meynert in Lewy body dementia: the role of Lewy bodies

Abstract Neurons of the nucleus basalis of Meynert (nbM) are vulnerable to Lewy body formation and neuronal loss, which is thought to underlie cognitive dysfunction in Lewy body dementia (LBD). There is continued debate about whether Lewy bodies exert a neurodegenerative effect by affecting mitochon...

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Bibliographic Details
Main Authors: Christopher Hatton, Amy Reeve, Nichola Zoe Lax, Alasdair Blain, Yi Shiau Ng, Omar El-Agnaf, Johannes Attems, John-Paul Taylor, Doug Turnbull, Daniel Erskine
Format: Article
Language:English
Published: BMC 2020-07-01
Series:Acta Neuropathologica Communications
Subjects:
Acetylcholine
Lewy body dementia
Alpha-synuclein
Mitochondria
Online Access:http://link.springer.com/article/10.1186/s40478-020-00985-8

Internet

http://link.springer.com/article/10.1186/s40478-020-00985-8

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