Dnase1L3 Regulates Inflammasome-Dependent Cytokine Secretion

Dnase1L3 Regulates Inflammasome-Dependent Cytokine Secretion

Pediatric-onset systemic lupus erythematosus arises in humans and mice lacking the endonuclease Dnase1L3. When Dnase1L3 is absent, DNA from circulating apoptotic bodies is not cleared, leading to anti-DNA antibody production. Compared to early anti-DNA and anti-chromatin responses, other autoantibod...

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Bibliographic Details
Main Authors: Guilan Shi, Kennady N. Abbott, Wenbo Wu, Russell D. Salter, Peter A. Keyel
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-05-01
Series:Frontiers in Immunology
Subjects:
cell activation
inflammation
macrophages
autoimmunity
systemic lupus erythematosus
Dnase gamma
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2017.00522/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2017.00522/full

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