Structure of PINK1 and mechanisms of Parkinson's disease-associated mutations

Structure of PINK1 and mechanisms of Parkinson's disease-associated mutations

Mutations in the human kinase PINK1 (hPINK1) are associated with autosomal recessive early-onset Parkinson's disease (PD). hPINK1 activates Parkin E3 ligase activity, involving phosphorylation of ubiquitin and the Parkin ubiquitin-like (Ubl) domain via as yet poorly understood mechanisms. hPINK...

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Bibliographic Details
Main Authors: Atul Kumar, Jevgenia Tamjar, Andrew D Waddell, Helen I Woodroof, Olawale G Raimi, Andrew M Shaw, Mark Peggie, Miratul MK Muqit, Daan MF van Aalten
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2017-10-01
Series:eLife
Subjects:
PINK1
structure
tribolium
Online Access:https://elifesciences.org/articles/29985

Internet

https://elifesciences.org/articles/29985

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