Early Developmental Marginal Zinc Deficiency Affects Neurogenesis Decreasing Neuronal Number and Altering Neuronal Specification in the Adult Rat Brain

Early Developmental Marginal Zinc Deficiency Affects Neurogenesis Decreasing Neuronal Number and Altering Neuronal Specification in the Adult Rat Brain

During pregnancy, a decreased availability of zinc to the fetus can disrupt the development of the central nervous system leading to defects ranging from severe malformations to subtle neurological and cognitive effects. We previously found that marginal zinc deficiency down-regulates the extracellu...

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Bibliographic Details
Main Authors: Ana M. Adamo, Xiuzhen Liu, Patricia Mathieu, Johnathan R. Nuttall, Suangsuda Supasai, Patricia I. Oteiza
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-03-01
Series:Frontiers in Cellular Neuroscience
Subjects:
zinc
brain development
ERK1/2
Tbr2
zinc deficiency
Online Access:https://www.frontiersin.org/article/10.3389/fncel.2019.00062/full

Internet

https://www.frontiersin.org/article/10.3389/fncel.2019.00062/full

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