Human alveolar epithelial cells type II are capable of TGFβ-dependent epithelial-mesenchymal-transition and collagen-synthesis

Human alveolar epithelial cells type II are capable of TGFβ-dependent epithelial-mesenchymal-transition and collagen-synthesis

Abstract Background The origin of collagen-producing cells in lung fibrosis is unclear. The involvement of embryonic signaling pathways has been acknowledged and trans-differentiation of epithelial cells is discussed critically. The work presented here investigates the role of TGFB in cytoskeleton r...

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Bibliographic Details
Main Authors: Torsten Goldmann, Gernot Zissel, Henrik Watz, Daniel Drömann, Martin Reck, Christian Kugler, Klaus F. Rabe, Sebastian Marwitz
Format: Article
Language:English
Published: BMC 2018-07-01
Series:Respiratory Research
Subjects:
EMT
Alveolar epithelial cells
Fibrosis
Collagen
Online Access:http://link.springer.com/article/10.1186/s12931-018-0841-9

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http://link.springer.com/article/10.1186/s12931-018-0841-9

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