GDNF Up-Regulates c-Myc Transcription via the PI3K/Akt Pathway to Promote Dairy Goat Male Germline Stem Cells (mGSC) Proliferation

GDNF Up-Regulates c-Myc Transcription via the PI3K/Akt Pathway to Promote Dairy Goat Male Germline Stem Cells (mGSC) Proliferation

Studies have demonstrated that regulation of GDNF on male germline stem cells (mGSCs) mainly through Ras/Erk1/2, Src family kinase and PI3K/Akt signaling pathways, but the signaling pathways GDNF-mediated are different when the species and cell lines varied. Whether GDNF regulates self-renewal of mG...

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Bibliographic Details
Main Authors: Jun-wei SUN, Hai-jing ZHU, Chao LIU, Ming-zhao LI, Jin-lian HUA
Format: Article
Language:English
Published: Elsevier 2013-06-01
Series:Journal of Integrative Agriculture
Subjects:
GDNF
male germline stem cells (mGscs)
PI3K/Akt
c-Myc
Online Access:http://www.sciencedirect.com/science/article/pii/S2095311913604840

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http://www.sciencedirect.com/science/article/pii/S2095311913604840

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