M. tuberculosis induces potent activation of IDO-1, but this is not essential for the immunological control of infection.

M. tuberculosis induces potent activation of IDO-1, but this is not essential for the immunological control of infection.

Indoleamine 2,3-dioxygenesae-1 (IDO-1) catalyses the initial, rate-limiting step in tryptophan metabolism, thereby regulating tryptophan availability and the formation of downstream metabolites, including picolinic and quinolinic acid. We found that Mycobacterium tuberculosis infection induced marke...

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Bibliographic Details
Main Authors: Antje Blumenthal, Gayathri Nagalingam, Jennifer H Huch, Lara Walker, Gilles J Guillemin, George A Smythe, Sabine Ehrt, Warwick J Britton, Bernadette M Saunders
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3359358?pdf=render

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http://europepmc.org/articles/PMC3359358?pdf=render

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