Tanc2-mediated mTOR inhibition balances mTORC1/2 signaling in the developing mouse brain and human neurons

Tanc2-mediated mTOR inhibition balances mTORC1/2 signaling in the developing mouse brain and human neurons

Alterations of the mTOR signalling pathway are associated with neurodevelopmental defects. Regulators of the mTOR kinase activity are not fully described. Here, the authors show that Tanc2, a scaffolding protein, acts as a direct inhibitor of mTOR kinase activity in the developing mouse brain and cu...

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Bibliographic Details
Main Authors: Sun-Gyun Kim, Suho Lee, Yangsik Kim, Jieun Park, Doyeon Woo, Dayeon Kim, Yan Li, Wangyong Shin, Hyunjeong Kang, Chaehyun Yook, Minji Lee, Kyungdeok Kim, Junyeop Daniel Roh, Jeseung Ryu, Hwajin Jung, Seung Min Um, Esther Yang, Hyun Kim, Jinju Han, Won Do Heo, Eunjoon Kim
Format: Article
Language:English
Published: Nature Publishing Group 2021-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-22908-4

Internet

https://doi.org/10.1038/s41467-021-22908-4

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