The Esophageal Organoid System Reveals Functional Interplay Between Notch and Cytokines in Reactive Epithelial Changes

The Esophageal Organoid System Reveals Functional Interplay Between Notch and Cytokines in Reactive Epithelial Changes

Aberrations in the esophageal proliferation-differentiation gradient are histologic hallmarks in eosinophilic esophagitis (EoE) and gastroesophageal reflux disease. A reliable protocol to grow 3-dimensional (3D) esophageal organoids is needed to study esophageal epithelial homeostasis under physiolo...

Full description

Bibliographic Details
Main Authors: Yuta Kasagi, Prasanna M. Chandramouleeswaran, Kelly A. Whelan, Koji Tanaka, Veronique Giroux, Medha Sharma, Joshua Wang, Alain J. Benitez, Maureen DeMarshall, John W. Tobias, Kathryn E. Hamilton, Gary W. Falk, Jonathan M. Spergel, Andres J. Klein-Szanto, Anil K. Rustgi, Amanda B. Muir, Hiroshi Nakagawa
Format: Article
Language:English
Published: Elsevier 2018-01-01
Series:Cellular and Molecular Gastroenterology and Hepatology
Subjects:
Three-Dimensional
Keratinocytes
Eosinophilic Esophagitis
Squamous Cell Differentiation
Online Access:http://www.sciencedirect.com/science/article/pii/S2352345X17301923

Internet

http://www.sciencedirect.com/science/article/pii/S2352345X17301923

Similar Items