MicroRNA-153 impairs presynaptic plasticity by blocking vesicle release following chronic brain hypoperfusion

MicroRNA-153 impairs presynaptic plasticity by blocking vesicle release following chronic brain hypoperfusion

Abstract Background Chronic brain hypoperfusion (CBH) is closely related to Alzheimer’s disease (AD) and vascular dementia (VaD). Meanwhile, synaptic pathology plays a prominent role in the initial stage of AD and VaD. However, whether and how CBH impairs presynaptic plasticity is currently unclear....

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Main Authors: Mei-Ling Yan, Shuai Zhang, Hong-Mei Zhao, Sheng-Nan Xia, Zhuo Jin, Yi Xu, Lin Yang, Yang Qu, Si-Yu Huang, Ming-Jing Duan, Meng Mao, Xiao-Bin An, Chandan Mishra, Xin-Yu Zhang, Li-Hua Sun, Jing Ai
Format: Article
Language:English
Published: BMC 2020-04-01
Series:Cell Communication and Signaling
Subjects:
Chronic brain hypoperfusion
Presynaptic plasticity
microRNA-153
Synaptic vesicle fusion
Low cerebral blood flow
Online Access:http://link.springer.com/article/10.1186/s12964-020-00551-8

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http://link.springer.com/article/10.1186/s12964-020-00551-8

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