Mapping person-to-person variation in viral mutations that escape polyclonal serum targeting influenza hemagglutinin
A longstanding question is how influenza virus evolves to escape human immunity, which is polyclonal and can target many distinct epitopes. Here, we map how all amino-acid mutations to influenza’s major surface protein affect viral neutralization by polyclonal human sera. The serum of some individua...
Main Authors: | , , , , , , , , , , , |
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Format: | Article |
Language: | English |
Published: |
eLife Sciences Publications Ltd
2019-08-01
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Series: | eLife |
Subjects: | |
Online Access: | https://elifesciences.org/articles/49324 |