Unexpected long-term protection of adult offspring born to high-fat fed dams against obesity induced by a sucrose-rich diet.

BACKGROUND: Metabolic and endocrine environment during early life is crucial for metabolic imprinting. When dams were fed a high fat diet (HF diet), rat offspring developed hypothalamic leptin resistance with lean phenotype when weaned on a normal diet. Interestingly, when grown on the HF diet, they...

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Bibliographic Details
Main Authors: Odile Couvreur, Jacqueline Ferezou, Daniel Gripois, Colette Serougne, Delphine Crépin, Alain Aubourg, Arieh Gertler, Claire-Marie Vacher, Mohammed Taouis
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3064582?pdf=render