Thrombospondin expression in myofibers stabilizes muscle membranes

Thrombospondin expression in myofibers stabilizes muscle membranes

Skeletal muscle is highly sensitive to mutations in genes that participate in membrane stability and cellular attachment, which often leads to muscular dystrophy. Here we show that Thrombospondin-4 (Thbs4) regulates skeletal muscle integrity and its susceptibility to muscular dystrophy through organ...

Full description

Bibliographic Details
Main Authors: Davy Vanhoutte, Tobias G Schips, Jennifer Q Kwong, Jennifer Davis, Andoria Tjondrokoesoemo, Matthew J Brody, Michelle A Sargent, Onur Kanisicak, Hong Yi, Quan Q Gao, Joseph E Rabinowitz, Talila Volk, Elizabeth M McNally, Jeffery D Molkentin
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2016-09-01
Series:eLife
Subjects:
intracellular trafficking
thrombospondin
Muscular Dystrophy
Online Access:https://elifesciences.org/articles/17589

Internet

https://elifesciences.org/articles/17589

Similar Items