Thrombospondin expression in myofibers stabilizes muscle membranes
Skeletal muscle is highly sensitive to mutations in genes that participate in membrane stability and cellular attachment, which often leads to muscular dystrophy. Here we show that Thrombospondin-4 (Thbs4) regulates skeletal muscle integrity and its susceptibility to muscular dystrophy through organ...
Main Authors: | Davy Vanhoutte, Tobias G Schips, Jennifer Q Kwong, Jennifer Davis, Andoria Tjondrokoesoemo, Matthew J Brody, Michelle A Sargent, Onur Kanisicak, Hong Yi, Quan Q Gao, Joseph E Rabinowitz, Talila Volk, Elizabeth M McNally, Jeffery D Molkentin |
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Format: | Article |
Language: | English |
Published: |
eLife Sciences Publications Ltd
2016-09-01
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Series: | eLife |
Subjects: | |
Online Access: | https://elifesciences.org/articles/17589 |
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