Orp8 deficiency in bone marrow-derived cells reduces atherosclerotic lesion progression in LDL receptor knockout mice.

Orp8 deficiency in bone marrow-derived cells reduces atherosclerotic lesion progression in LDL receptor knockout mice.

INTRODUCTION: Oxysterol binding protein Related Proteins (ORPs) mediate intracellular lipid transport and homeostatic regulation. ORP8 downregulates ABCA1 expression in macrophages and cellular cholesterol efflux to apolipoprotein A-I. In line, ORP8 knockout mice display increased amounts of HDL cho...

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Bibliographic Details
Main Authors: Erik van Kampen, Olivier Beaslas, Reeni B Hildebrand, Bart Lammers, Theo J C Van Berkel, Vesa M Olkkonen, Miranda Van Eck
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4209969?pdf=render

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http://europepmc.org/articles/PMC4209969?pdf=render

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