NLRP3 inflammasome inhibitor OLT1177 suppresses joint inflammation in murine models of acute arthritis

NLRP3 inflammasome inhibitor OLT1177 suppresses joint inflammation in murine models of acute arthritis

Abstract Background Activation of the NLRP3 inflammasome in gout amplifies the inflammatory response and mediates further damage. In the current study, we assessed the therapeutic effect of OLT1177, an orally active NLRP3 inflammasome inhibitor that is safe in humans, in murine acute arthritis model...

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Bibliographic Details
Main Authors: Carlo Marchetti, Benjamin Swartzwelter, Marije I. Koenders, Tania Azam, Isak W. Tengesdal, Nick Powers, Dennis M. de Graaf, Charles A. Dinarello, Leo A. B. Joosten
Format: Article
Language:English
Published: BMC 2018-08-01
Series:Arthritis Research & Therapy
Subjects:
IL-1β
NLRP3 inflammasome
Gout
Online Access:http://link.springer.com/article/10.1186/s13075-018-1664-2

Internet

http://link.springer.com/article/10.1186/s13075-018-1664-2

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