Conjugation with Dihydrolipoic Acid Imparts Caffeic Acid Ester Potent Inhibitory Effect on Dopa Oxidase Activity of Human Tyrosinase

Conjugation with Dihydrolipoic Acid Imparts Caffeic Acid Ester Potent Inhibitory Effect on Dopa Oxidase Activity of Human Tyrosinase

Caffeic acid derivatives represent promising lead compounds in the search for tyrosinase inhibitors to be used in the treatment of skin local hyperpigmentation associated to an overproduction or accumulation of melanin. We recently reported the marked inhibitory activity of a conjugate of caffeic ac...

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Bibliographic Details
Main Authors: Raffaella Micillo, Julia Sirés-Campos, José Carlos García-Borrón, Lucia Panzella, Alessandra Napolitano, Conchi Olivares
Format: Article
Language:English
Published: MDPI AG 2018-07-01
Series:International Journal of Molecular Sciences
Subjects:
caffeic acid
dihydrolipoic acid
tyrosinase
inhibition mechanism
dopa oxidase
skin lightening
depigmenting agent
Online Access:http://www.mdpi.com/1422-0067/19/8/2156

Internet

http://www.mdpi.com/1422-0067/19/8/2156

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