YAP Induces Human Naive Pluripotency

YAP Induces Human Naive Pluripotency

The human naive pluripotent stem cell (PSC) state, corresponding to a pre-implantation stage of development, has been difficult to capture and sustain in vitro. We report that the Hippo pathway effector YAP is nuclearly localized in the inner cell mass of human blastocysts. Overexpression of YAP in...

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Bibliographic Details
Main Authors: Han Qin, Miroslav Hejna, Yanxia Liu, Michelle Percharde, Mark Wossidlo, Laure Blouin, Jens Durruthy-Durruthy, Priscilla Wong, Zhongxia Qi, Jingwei Yu, Lei S. Qi, Vittorio Sebastiano, Jun S. Song, Miguel Ramalho-Santos
Format: Article
Language:English
Published: Elsevier 2016-03-01
Series:Cell Reports
Subjects:
embryonic stem cells (ESCs)
induced pluripotent stem cells (iPSCs)
pluripotent stem cells (PSCs)
naive pluripotency
Hippo pathway
Yes-associated protein (YAP)
lysophosphatidic acid (LPA)
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124716301395

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http://www.sciencedirect.com/science/article/pii/S2211124716301395

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