GPIHBP1 stabilizes lipoprotein lipase and prevents its inhibition by angiopoietin-like 3 and angiopoietin-like 4

GPIHBP1 stabilizes lipoprotein lipase and prevents its inhibition by angiopoietin-like 3 and angiopoietin-like 4

Glycosylphosphatidylinositol-anchored HDL-binding protein (GPIHBP1) binds both LPL and chylomicrons, suggesting that GPIHBP1 is a platform for LPL-dependent processing of triglyceride (TG)-rich lipoproteins. Here, we investigated whether GPIHBP1 affects LPL activity in the absence and presence of LP...

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Bibliographic Details
Main Authors: William K. Sonnenburg, Daiguan Yu, E-Chiang Lee, Wei Xiong, Gennady Gololobov, Billie Key, Jason Gay, Nat Wilganowski, Yi Hu, Sharon Zhao, Matthias Schneider, Zhi-Ming Ding, Brian P. Zambrowicz, Greg Landes, David R. Powell, Urvi Desai
Format: Article
Language:English
Published: Elsevier 2009-12-01
Series:Journal of Lipid Research
Subjects:
glycosylphosphatidylinositol-anchored HDL-binding protein
knockout mice
monoclonal antibodies
hypertriglyceridemia
chylomicronemia
ANGPTL4-neutralizing monoclonal antibody
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520306659

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http://www.sciencedirect.com/science/article/pii/S0022227520306659

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