Developmental exposure to the organochlorine pesticide dieldrin causes male-specific exacerbation of α-synuclein-preformed fibril-induced toxicity and motor deficits

Developmental exposure to the organochlorine pesticide dieldrin causes male-specific exacerbation of α-synuclein-preformed fibril-induced toxicity and motor deficits

Human and animal studies have shown that exposure to the organochlorine pesticide dieldrin is associated with increased risk of Parkinson's disease (PD). Previous work showed that developmental dieldrin exposure increased neuronal susceptibility to MPTP toxicity in male C57BL/6 mice, possibly v...

Full description

Bibliographic Details
Main Authors: Aysegul O. Gezer, Joseph Kochmanski, Sarah E. VanOeveren, Allyson Cole-Strauss, Christopher J. Kemp, Joseph R. Patterson, Kathryn M. Miller, Nathan C. Kuhn, Danielle E. Herman, Alyssa McIntire, Jack W. Lipton, Kelvin C. Luk, Sheila M. Fleming, Caryl E. Sortwell, Alison I. Bernstein
Format: Article
Language:English
Published: Elsevier 2020-07-01
Series:Neurobiology of Disease
Subjects:
Parkinson's
Pesticide
Synuclein
Neurotoxicity
Neuroinflammation
Sex differences
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996120302229

Internet

http://www.sciencedirect.com/science/article/pii/S0969996120302229

Similar Items