Endogenous Retrovirus-Derived Long Noncoding RNA Enhances Innate Immune Responses via Derepressing RELA Expression

Endogenous Retrovirus-Derived Long Noncoding RNA Enhances Innate Immune Responses via Derepressing RELA Expression

Endogenous retroviruses are transposable genetic elements comprising 8% to 10% of the human and mouse genomes. Although most ERVs have been inactivated due to deleterious mutations, some are still transcribed. However, the biological functions of transcribed ERVs are largely unknown. Here, we identi...

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Bibliographic Details
Main Authors: Bin Zhou, Fei Qi, Fangyi Wu, Hongbo Nie, Yifan Song, Lu Shao, Jingxuan Han, Zhen Wu, Hexige Saiyin, Gang Wei, Penghua Wang, Ting Ni, Feng Qian
Format: Article
Language:English
Published: American Society for Microbiology 2019-07-01
Series:mBio
Subjects:
nf-κb
antiviral immune responses
endogenous retroviruses
gene regulation
lncrna
Online Access:https://doi.org/10.1128/mBio.00937-19

Internet

https://doi.org/10.1128/mBio.00937-19

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