α-Synuclein accumulation and GBA deficiency due to L444P GBA mutation contributes to MPTP-induced parkinsonism

α-Synuclein accumulation and GBA deficiency due to L444P GBA mutation contributes to MPTP-induced parkinsonism

Abstract Background Mutations in glucocerebrosidase (GBA) cause Gaucher disease (GD) and increase the risk of developing Parkinson’s disease (PD) and Dementia with Lewy Bodies (DLB). Since both genetic and environmental factors contribute to the pathogenesis of sporadic PD, we investigated the susce...

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Bibliographic Details
Main Authors: Seung Pil Yun, Donghoon Kim, Sangjune Kim, SangMin Kim, Senthilkumar S. Karuppagounder, Seung-Hwan Kwon, Saebom Lee, Tae-In Kam, Suhyun Lee, Sangwoo Ham, Jae Hong Park, Valina L. Dawson, Ted M. Dawson, Yunjong Lee, Han Seok Ko
Format: Article
Language:English
Published: BMC 2018-01-01
Series:Molecular Neurodegeneration
Subjects:
Parkinson’s disease
GBA
MPTP
Mitochondrial dysfunction
α-synuclein
Online Access:http://link.springer.com/article/10.1186/s13024-017-0233-5

Internet

http://link.springer.com/article/10.1186/s13024-017-0233-5

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