Antitumor Activity of the Cardiac Glycoside α-L-Diginoside by Modulating Mcl-1 in Human Oral Squamous Cell Carcinoma Cells

We recently isolated a cardiac glycoside (CG), α-L-diginoside, from an indigenous plant in Taiwan, which exhibits potent tumor-suppressive efficacy in oral squamous cell carcinoma (OSCC) cell lines (SCC2095 and SCC4, IC<sub>50</sub> < 0.2 µM; 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenylt...

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Bibliographic Details
Main Authors: Jing-Ru Weng, Wei-Yu Lin, Li-Yuan Bai, Jing-Lan Hu, Chia-Hsien Feng
Format: Article
Language:English
Published: MDPI AG 2020-10-01
Series:International Journal of Molecular Sciences
Subjects:
Online Access:https://www.mdpi.com/1422-0067/21/21/7947