Sphingosine Kinases and Sphingosine 1-Phosphate Receptors: Signaling and Actions in the Cardiovascular System

Sphingosine Kinases and Sphingosine 1-Phosphate Receptors: Signaling and Actions in the Cardiovascular System

The sphingosine kinases 1 and 2 (SphK1 and 2) catalyze the phosphorylation of the lipid, sphingosine, generating the signal transmitter, sphingosine 1-phosphate (S1P). The activation of such kinases and the subsequent S1P generation and secretion in the blood serum of mammals represent a major check...

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Bibliographic Details
Main Authors: Alessandro Cannavo, Daniela Liccardo, Klara Komici, Graziamaria Corbi, Claudio de Lucia, Grazia D. Femminella, Andrea Elia, Leonardo Bencivenga, Nicola Ferrara, Walter J. Koch, Nazareno Paolocci, Giuseppe Rengo
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-08-01
Series:Frontiers in Pharmacology
Subjects:
sphingosine 1-phosphate
G protein-coupled receptors
sphingosine kinase
fingolimod
cardiovascular
heart failure
Online Access:http://journal.frontiersin.org/article/10.3389/fphar.2017.00556/full

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http://journal.frontiersin.org/article/10.3389/fphar.2017.00556/full

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