Opportunities and Challenges in Functional Genomics Research in Osteoporosis: Report From a Workshop Held by the Causes Working Group of the Osteoporosis and Bone Research Academy of the Royal Osteoporosis Society on October 5th 2020

Opportunities and Challenges in Functional Genomics Research in Osteoporosis: Report From a Workshop Held by the Causes Working Group of the Osteoporosis and Bone Research Academy of the Royal Osteoporosis Society on October 5th 2020

The discovery that sclerostin is the defective protein underlying the rare heritable bone mass disorder, sclerosteosis, ultimately led to development of anti-sclerostin antibodies as a new treatment for osteoporosis. In the era of large scale GWAS, many additional genetic signals associated with bon...

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Bibliographic Details
Main Authors: Jonathan H. Tobias, Emma L. Duncan, Erika Kague, Chrissy L. Hammond, Celia L. Gregson, Duncan Bassett, Graham R. Williams, Josine L. Min, Tom R. Gaunt, David Karasik, Claes Ohlsson, Fernando Rivadeneira, James R. Edwards, Fadil M. Hannan, John P. Kemp, Sophie J. Gilbert, Nerea Alonso, Neelam Hassan, Juliet E. Compston, Stuart H. Ralston
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-02-01
Series:Frontiers in Endocrinology
Subjects:
genome-wide association study
bone mineral density
mouse model
zebrafish
“omics” data
Online Access:https://www.frontiersin.org/articles/10.3389/fendo.2020.630875/full

Internet

https://www.frontiersin.org/articles/10.3389/fendo.2020.630875/full

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