Differences in Contractile Function of Myofibrils within Human Embryonic Stem Cell-Derived Cardiomyocytes vs. Adult Ventricular Myofibrils Are Related to Distinct Sarcomeric Protein Isoforms

Differences in Contractile Function of Myofibrils within Human Embryonic Stem Cell-Derived Cardiomyocytes vs. Adult Ventricular Myofibrils Are Related to Distinct Sarcomeric Protein Isoforms

Characterizing the contractile function of human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs) is key for advancing their utility for cellular disease models, promoting cell based heart repair, or developing novel pharmacological interventions targeting cardiac diseases. The aim of the pre...

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Bibliographic Details
Main Authors: Bogdan Iorga, Kristin Schwanke, Natalie Weber, Meike Wendland, Stephan Greten, Birgit Piep, Cristobal G. dos Remedios, Ulrich Martin, Robert Zweigerdt, Theresia Kraft, Bernhard Brenner
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-01-01
Series:Frontiers in Physiology
Subjects:
human pluripotent stem cell-derived cardiomyocytes
human embryonic stem cell-derived cardiomyocytes
hiPSC-CMs maturation
human cardiomyocytes development
adult human ventricular myofibrils
cardiac contractile function
Online Access:http://journal.frontiersin.org/article/10.3389/fphys.2017.01111/full

Internet

http://journal.frontiersin.org/article/10.3389/fphys.2017.01111/full

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