Non-Mendelian Dominant Maternal Effects Caused by CRISPR/Cas9 Transgenic Components in Drosophila melanogaster

Non-Mendelian Dominant Maternal Effects Caused by CRISPR/Cas9 Transgenic Components in Drosophila melanogaster

The CRISPR/Cas9 system has revolutionized genomic editing. The Cas9 endonuclease targets DNA via an experimentally determined guide RNA (gRNA). This results in a double-strand break at the target site . We generated transgenic Drosophila melanogaster in which the CRISPR/Cas9 system was used to targe...

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Bibliographic Details
Main Authors: Chun-Chieh Lin, Christopher J. Potter
Format: Article
Language:English
Published: Oxford University Press 2016-11-01
Series:G3: Genes, Genomes, Genetics
Subjects:
gene drive
maternal effect
HACK
mutagenic chain reaction
MCR
Online Access:http://g3journal.org/lookup/doi/10.1534/g3.116.034884

Internet

http://g3journal.org/lookup/doi/10.1534/g3.116.034884

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