Rationally Designed Influenza Virus Vaccines That Are Antigenically Stable during Growth in Eggs
Influenza virus vaccine production is currently limited by the ability to grow circulating human strains in chicken eggs or in cell culture. To facilitate cost-effective growth, vaccine strains are serially passaged under production conditions, which frequently results in mutations of the major anti...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
American Society for Microbiology
2017-06-01
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| Series: | mBio |
| Online Access: | http://mbio.asm.org/cgi/content/full/8/3/e00669-17 |