Human amyloid-β enriched extracts: evaluation of in vitro and in vivo internalization and molecular characterization

Human amyloid-β enriched extracts: evaluation of in vitro and in vivo internalization and molecular characterization

Abstract Background Intracerebral inoculation of extracts from post-mortem human Alzheimer’s disease brains into mice produces a prion-like spreading effect of amyloid-β. The differences observed between these extracts and the synthetic peptide, in terms of amyloid-β internalization and seed and cel...

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Main Authors: Cristina M. Pedrero-Prieto, Alicia Flores-Cuadrado, Daniel Saiz-Sánchez, Isabel Úbeda-Bañón, Javier Frontiñán-Rubio, Francisco J. Alcaín, Lourdes Mateos-Hernández, José de la Fuente, Mario Durán-Prado, Margarita Villar, Alino Martínez-Marcos, Juan R. Peinado
Format: Article
Language:English
Published: BMC 2019-06-01
Series:Alzheimer’s Research & Therapy
Subjects:
Alzheimer’s disease
Amyloid-β
Prion-like hypothesis
Amyloid-β internalization
Proteomics
Online Access:http://link.springer.com/article/10.1186/s13195-019-0513-0

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http://link.springer.com/article/10.1186/s13195-019-0513-0

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