Cyclizing Painkillers: Development of Backbone-Cyclic TAPS Analogs

Cyclizing Painkillers: Development of Backbone-Cyclic TAPS Analogs

Painkillers are commonly used medications. Native peptide painkillers suffer from various pharmacological disadvantages, while small molecule painkillers like morphine are highly addictive. We present a general approach aimed to use backbone-cyclization to develop a peptidomimetic painkiller. Backbo...

Full description

Bibliographic Details
Main Authors: Alaa Talhami, Avi Swed, Shmuel Hess, Oded Ovadia, Sarit Greenberg, Adi Schumacher-Klinger, David Rosenthal, Deborah E. Shalev, Mattan Hurevich, Philip Lazarovici, Amnon Hoffman, Chaim Gilon
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-11-01
Series:Frontiers in Chemistry
Subjects:
reductive alkylation
backbone cyclization
cycloscan
TAPS
peripheral painkiller
Online Access:https://www.frontiersin.org/articles/10.3389/fchem.2020.532577/full

Internet

https://www.frontiersin.org/articles/10.3389/fchem.2020.532577/full

Similar Items